. Udupa, A; Nahar, P; Shah, S; Kshirsagar, M; Ghongane, B 2013-07-01 Diabetes Mellitus is a metabolic disorder characterized by abnormal lipid and glucose metabolism.
Various modes of adjuvant therapy have been advocated to ameliorate insulin resistance. This study was intended to assess the effects of antioxidants; alpha lipoic acid (ALA), omega 3 fatty acid and vitamin E on parameters of insulin sensitivity (blood glucose and HbA1c) in patients of type 2 diabetes mellitus with documented insulin resistance. It was a prospective, randomized, double blind, placebo controlled, single centered study.
104 patients with type 2 diabetes mellitus with insulin resistance were recruited. They were given ALA, omega 3 fatty acid, vitamin E or placebo. Fasting blood glucose and HbA1c were measured at first visit (V1) and after 90 days (V2).
Statistical analysis was carried out by paired t-test by using SPSS software version 11 (SPSS, Chicago, USA). Analysis of baseline (V1) vs. End of treatment period (V2) parameters, showed significant decrease in HbA1c in the three treatment group. We also observed decrease in fasting blood glucose in the three treatment group but it was not statistically significant (Gr.
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I = 0.51, Gr. II = 0.05, Gr. III = 0.22, Gr. ALA, Omega 3 fatty acid and vitamin E can be used as add on therapy in patients with type 2 diabetes mellitus to improve insulin sensitivity and lipid metabolism. Zheng, Yan; Li, Yanping; Qi, Qibin; Hruby, Adela; Manson, JoAnn E; Willett, Walter C; Wolpin, Brian M; Hu, Frank B; Qi, Lu 2016-01-01 Background: Plasma branched-chain amino acids (BCAAs, including leucine, isoleucine and valine) were recently related to risk of type 2 diabetes (T2D).
Dietary intake is the only source of BCAAs; however, little is known about whether habitual dietary intake of BCAAs affects risk of T2D. Methods: We assessed associations between cumulative consumption of BCAAs and risk of T2D among participants from three prospective cohorts: the Nurses’ Health Study (NHS; followed from 1980 to 2012); NHS II (followed from 1991 to 2011); and the Health Professionals Follow-up Study (HPFS; followed from 1986 to 2010). Results: We documented 16 097 incident T2D events during up to 32 years of follow-up. After adjustment for demographics and traditional risk factors, higher total BCAA intake was associated with an increased risk of T2D in men and women. In the meta-analysis of all cohorts, comparing participants in the highest quintile with those in the lowest quintile of intake, hazard ratios (95%confidence intervals) were for leucine 1.13 (1.07-1.19), for isoleucine 1.13 (1.07-1.19) and for valine 1.11 (1.05-1.17) (all P for trend.
1.Define,enerali#ed $oo%&s law. 2.Differentiate between eCternal forces and internal forces. 3.ECplain the different types of stress.:rite a short notes on principle of super position.? Differentiate between body forces and surface forces. 8.Define stress at a point 9.Define plane stress and,iAe an eCample.
5.Define plane strain and,iAe an eCample. 4.ind the minimum diameter of a steel wire which is usin, to raise a load of.